サフランエキスの効能

その効能が注目されている故に、多くの臨床試験が行われています。

睡眠の質の向上

Masaki M, Aritake K, Tanaka H, Shoyama Y, Huang ZL, Urade Y. Crocin promotes non-rapid eye movement sleep in mice. Mol Nutr Food Res. 2012 Feb;56(2):304-308＜動物実験による参考データ＞

うつ症状・気分の改善

• Graham Kell, Amanda Rao, Gavin Beccaria, Paul Clayton, Antonio Manuel Inarejos-García, Marin Prodanov, affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebocontrolled clinical trial, Complementary Therapies in Medicine 33 (2017) 58–64
• Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F., Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]., BMC Complement Altern Med. 2004 Sep 2;4:12
• Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2015 Mar 15;174:51-56

記憶障害の改善

• Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A., Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial., J Clin Pharm Ther. 2010 Oct;35(5):581-8.
• Farokhnia M, Shafiee Sabet M, Iranpour N, Gougol A, Yekehtaz H, Alimardani R, Farsad F, Kamalipour M, Akhondzadeh S., Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer’s disease: a double-blind randomized clinical trial., Hum Psychopharmacol. 2014 Jul;29(4):351-9.

PMSの緩和

• Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, Akhondzadeh S. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008 Mar;115(4):515-519
• Soheila Pirdadeh Beiranvand, Nabiollah Shams Beiranvand, Zahra Behboodi Moghadam, Mehdi Birjandi, Seddigheh Azhari, Elham Rezaei, Ali Nazar Salehnia, Somayyeh Beiranvand, The effect of Crocus sativus (saffron) on the severity of premenstrual syndrome, European Journal of Integrative Medicine, Available online 2 July 2015,

性機能障害の改善

• Cai T, Morgia G, Carrieri G, Terrone C, Imbimbo C, Verze P, Mirone V; IDIProst® Gold Study Group., An improvement in sexual function is related to better quality of life, regardless of urinary function improvement: results from the IDIProst® Gold Study., Arch Ital Urol Androl. 2013 Dec 31;85(4):184-189
• Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study., Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, Jamshidi A, Ashrafi M, Mansouri P, Ghaeli P, Akhondzadeh S., Hum Psychopharmacol. 2013 Jan;28(1):54-60

メタボリックシンドロームの緩和

• Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Ghayour-Mobarhan M, Ferns GA., Saffron in metabolic syndrome: its effects on antibody titers to heat-shock proteins 27, 60, 65 and 70., J Complement Integr Med. 2014 Feb 6;11(1):43-9
• Saffron aqueous extract prevents metabolic syndrome in patients with schizophrenia on olanzapine treatment: a randomized triple blind placebo controlled study., Fadai F, Mousavi B, Ashtari Z, Ali beigi N, Farhang S, Hashempour S, Shahhamzei N, Bathaie SZ., Pharmacopsychiatry. 2014 Jul;47(4-5):156-61

筋肉痛の改善

• Meamarbashi A, Rajabi A., Preventive effects of 10-day supplementation with saffron and indomethacin on the delayed-onset muscle soreness., Clin J Sport Med. 2015 Mar;25(2):105-112